William Kisseberth, DVM, MS, PhD, and Dean Lee, MD, PhD, collaborated to use a natural animal model of disease, specifically dogs with tumors, to test the safety and efficacy of a new therapy for treating bone tumors. These canine tumors are very similar to those found in people, making the model especially effective for validating the therapy before moving to human clinical trials. Dr. Kisseberth is Professor of Veterinary Clinical Sciences in the College of Veterinary Medicine at Ohio State and Dr. Lee is Professor of Pediatrics and he DiMarco Family Endowed Chair in Cell Based Therapy at Nationwide Children's Hospital and the Ohio State College of Medicine.

This is the third in a series of programs from the Ohio State Center for Clinical and Translational Science Comparative and Translational Medicine program highlighting how the use of spontaneous animal models of disease can create an integrated platform for collaborative research, therapeutic interrogation, cross-disciplinary training and outreach across Ohio State, Nationwide Children's Hospital, and partners.

When: April 24, 2024, noon - 1 p.m. EST

Where: Online

Register for this event

Mark your calendar for July 26 at Noon for the next program in the series, Testing a Wearable Joint Monitoring Device on Dogs.

Sarah Moore, DVM, Diplomate ACVIM (Neurology)

Wolfe Associates Endowed Professor in Canine Clinical and Comparative Medicine 

College of Veterinary Medicine, Department of Veterinary Clinical Sciences

Devina Purmessur (Walter), PhD

Assistant Professor

College of Engineering, Department of Biomedical Engineering

Devina Purmessur, PhD, from the College of Engineering, and Sarah Moore, DVM, from the College of Veterinary Medicine, will discuss how they teamed up to use spontaneous animal models of spinal disease to help identify novel treatment strategies for back pain and other chronic pain conditions. Their collaborative efforts involve both mice and dogs with degenerative disc disease, and the presentation will highlight the advantages of spontaneous animal models for translational research.

Ian C. Davis, PhD, and Anda Young, DVM, of the Ohio State University College of Veterinary Medicine will describe how they used client-owned dogs admitted to the small animal ICU at The Ohio State University Veterinary Medical Center as a “real-world” model to test the repurposing of an old drug, citicoline, as a treatment for hypoxemic acute respiratory failure. Drs. Davis and Young were able to assess treatment efficacy in a natural disease state in outbred animals of different ages and both sexes. Come to learn about how they came to use this model and their results.