Multicenter Research Study Support
The Network Capacity Program aims to enhance the quality, efficiency, safety and effectiveness of multi-site clinical research studies through dissemination of adopted best practices and shared resources for Ohio State and Nationwide Children's Hospital investigators. The Network Capacity Program provides an array of multi-site clinical research services and support including the assistance with the development of study organizational and leadership plans, study budgets, SIRB plans, DSMB plans, Manual of Procedures and training of Project Managers of investigator-initiated multi-site clinical research studies.
Ohio State Center for Clinical and Translational Science (CCTS) is committed to strengthening relations within the translational community at Ohio State as well as colleagues at other CTSA institutions and research networks. We are a founding member of three clinical research collaborative networks offering Ohio State investigators access to multiple research sites, shared infrastructure and operational efficiencies to improve the quality, speed and performance of your clinical research study.
For more information, request a service through MyCCTS.
Trial Innovation Network
The Trial Innovation Network (TIN) began in 2016 collaborative initiative amongst Clinical and Translational Science Award (CTSA) institutions in which the primary objective is to enhance multi-site trial operations by leveraging the resources and collective expertise of CTSA members to provide complementary services for all aspects of proposal development and execution. The TIN mission is to address critical roadblocks in clinical research and accelerate the translation of novel interventions into life-saving therapies.
The TIN has a two-fold functionality: it is a pathway connecting Ohio State and Nationwide Children’s Hospital investigators to potential collaborators from other CTSA institutions and resources to strengthen their proposals and to execute proposals better, faster and more cost-effectively. In addition, the TIN facilitates strategic partnerships by assisting investigators from other CTSA institutions to identify collaborators at Ohio State and Nationwide Children’s Hospital based on targeted feasibility assessments.
Access the TIN Overview and Getting Started Handout
The TIN is comprised of three key organizational partners:
Trial Innovation Centers (TICs)
The National Trial Innovation Centers (TICS) focus on operational excellence, operational innovation and quality by design. The TICs responsible for coordinating and providing innovative, high-quality operational support for clinical trials. There are three TICs:
- Duke University / Vanderbilt University
- John Hopkins University / Tufts University
- University of Utah
Recruitment Innovation Centers (RICs)
The National Recruitment Innovation Center (RIC) focused on innovative and evidence-based approaches to participant recruitment, retention and engagement. The RIC is responsible for providing tools and services to enhance participant recruitment and retention.
- Vanderbilt University with partners at Columbia University, University of Utah, Rockefeller University and The Ohio State University
TIN Hub Liaison Team
The Local TIN Hub Liaison Team is the frontline of the TIN leading the Network at the local level by connecting the Hub to the TICs and RIC.
- Ohio State CCTS is a TIN Hub Liaison Team
In addition, the TIN provides Trial Planning and Trial Execution Services.
Trial Planning: Initial Consultations
- Protocol Design
- Study and Budget Feasibility
- Statistical Analysis Plan
- Risk Assessment
- Engagement and Recruitment Plans
- Patient Engagement Studio
- Cohort Discover Leveraging EHR
- Recruitment Training
- Access to unique populations - Rare Diseases
- Key Opinion Leader/Clinical Expertise
Trial Execution Services
- Serve as a Central IRB for your multi-site proposal
- Implement Standard Clinical Trial Agreements for your multi-site proposal
- Provide clinical and data coordinating center services such as regulatory support, project management, data management, development of consent form and case report forms, site selection, initiation and training, performance metrics, Data Safety Monitoring Board (DSMB), study close-out, statistical analysis and publication
- Evaluation and improvement in recruitment plans and tools
Who We Are
The Ohio State University Hub Liaison Team
Medical Director: Henry Wang, MD
TIN Hub Administrator: Amy Bartlett, BA, CCRC
Liaison Team Staff
Recruitment Program Coordinator: Mary Becker
IRB Specialist: Melanie Howell
FDP-CTSA Standard Agreements Specialists: Aimee Nielsen-Link
Regulatory Affairs Specialist: April Green, MACPR, CCRC
Navigating the complicated clinical research landscape can be challenging especially when conducting one’s own investigator-initiated multi-site study. The goal of the TIN is to address the critical roadblocks in clinical trials and accelerate the translation of novel interventions into life-saving therapies. By focusing on operational innovation, operational excellence and collaboration, the TIN supports investigators develop and implement multi-site clinical trials better, faster and more cost-effectively.
- Complimentary services
- Pipeline for finding the collaborators
- Increased competitiveness of applications for NIH
- Access to expertise in multi-center operations (TICs and the RIC) enabling better implementation
If you are interested in submitting a proposal to the TIN, you must contact the Ohio State Hub Liaison Team first for an initial review of your proposal, brief consultation and review by local scientific review committee. Please contact Amy Bartlett, TIN Hub Liaison Team Administrator at 614-247-7732 with questions.
Collaborative Networks
Pragmatic Clinical Trials Network
Pragmatic Clinical Trials Network is a partnership between the Division of General Internal Medicine, the Clinical Trials Management Office and the Center for Clinical and Translational Science at The Ohio State University.
The Division of General Internal Medicine (GIM), the Clinical Trials Management Office (CTMO), and the Center for Clinical and Translational Science (CCTS) have partnered to develop infrastructure and mechanisms for implementing clinical trials in the GIM primary care clinics.
Why should I consider implementing a clinical trial in the GIM Primary Care Clinics?
- The GIM Primary Care Clinical Network consists of 6 clinical sites and a home visit primary care program, geographically spread throughout the greater Columbus area
- GIM clinical providers collectively care for over 26,000 patients, a majority of whom have multiple chronic diseases
- Many network providers care for special populations, including pediatric, disabled, transition and home-bound patients
- Each GIM clinical site has primary care providers and clinical researchers who have completed regulatory and ethical training in human subjects research
- The GIM clinical sites collaborate closely with the CTMO and CCTS through every stage of clinical trial evaluation, implementation and recruitment
- The GIM clinical sites are a part of the Ohio Clinical Trials Collaborative (OCTC), a statewide network of primary care clinics that are prepared to conduct clinical trials that can work with researchers to disseminate their clinical trial to all of the clinics in the OCTC Network
How do I know if a trial is right for implementation in the GIM primary care clinics?
GIM primary care providers care for a vast array of conditions. Commonly managed chronic disease issues include, but are not limited to:
- Cardiovascular: Hypertension, Hyperlipidemia, Coronary Artery Disease, Congestive Heart Failure and Anti-Coagulation Monitoring
- Pulmonary: Asthma, Chronic Obstructive Pulmonary Disease
- Gastrointestinal: Gastro-Esophageal Reflux Disease, Irritable Bowel Syndrome
- Renal: Chronic Kidney Disease
- Endocrine: Diabetes Mellitus, Hypothyroidism
- Psychiatric: Depression, Anxiety, Attention Deficit (Hyperactive) Disorder
- Genetic/ Developmental: Autism, Down Syndrome
- Other: Chronic Pain, Obesity, Tobacco Abuse
If you have a clinical trial that may be appropriate for the GIM Primary Care Clinical Network, please contact the following individuals:
Dr. Seuli Brill
Director, Pragmatic Clinical Trials Network
Research Director, Division of General Internal Medicine
Laura Miles
Clinical Research Coordinator
Division of General Internal Medicine
Ohio Clinical Trials Network (OCTC)
Established in May 2013, the Ohio Clinical Trials Collaborative (OCTC) is a statewide model comprised of Ohio's three Clinical and Translational Science Awards (CTSA) - The Ohio State University Center for Clinical and Translational Science, Clinical and Translational Science Collaborative (CTSC) of Cleveland, and the University of Cincinnati Center for Clinical and Translational Science and Training - that initiated discussions to develop this clinical trials concept statewide.
In addition to the three CTSA sites, partners in the statewide network include: Cincinnati Children's Hospital Medical Center, Cleveland Clinic, MetroHealth Medical Center, Nationwide Children's Hospital, Practice Based Research Network and University Hospitals Case Medical Center. In partnership with the State of Ohio, OCTC will contribute to the success of Governor Kasich's vision for a statewide Medical Corridor. Contact Amy Bartlett with questions.
Midwest Area Research Consortium for Health (MARCH)
The Midwest Area Research Consortium for Health (MARCH) provides an established infrastructure for investigators and external sponsors who want to conduct collaborative clinical research at academic institutions across the Midwest. MARCH aims to promote collaboration opportunities to enhance ethnic diversity and demographic variety in clinical research, provide access to large sample size research across multiple sites and increase opportunities to conduct research on rare diseases.
MARCH provides opportunities for improved efficiency through reciprocal IRB deferral agreements, accessible clinical research management tools, enhanced participant recruitment via multi-site research studies and simplified fiscal management. Contact Amy Bartlett with questions.
Appalachian Translational Research Network (ATRN)
The Appalachian Translational Research Network (ATRN) is committed to addressing the significant health challenges and disparities specific to Appalachia by enhancing research collaborations to speed the translation of scientific discoveries to health improvements for this region.
The ATRN seeks to foster Community Engagement and Outreach to those in the Appalachian region. In addition, the ATRN will serve as a conduit for enhancing T1 research collaborations in areas relevant to the chronic health conditions prevalent in Appalachia.
Strategic Pharma-Academic Research Consortium for Translational Medicine (SPARC)
The Strategic Pharma-Academic Research Consortium for Translational Medicine (SPARC) is an organization designed to spark innovative collaborations across academic research centers and the biopharmaceutical industry. The program includes a list of inaugural members made up of four academic medical centers supported by the NIH Clinical and Translational Science Awards, as well as two major pharmaceutical companies, Eli Lilly and Co. and Takeda Pharmaceuticals International Inc.
SPARC was born in July 2012, when the Indiana Clinical and Translational Science Institute (CTSI) hosted a first-of-its-kind meeting to discuss potential partnerships among 17 directors of CTSA-funded centers, university technology transfer officers and industry. The inaugural CTSA-funded institutions to join the consortium are: The Indiana Clinical and Translational Science Institute; The Ohio State University Center for Clinical and Translational Science; Northwestern University Clinical and Translational Sciences Institute; and The Institute of Clinical and Translational Sciences at Washington University in St. Louis.
The consortium will initially focus on advancing research on autoimmune diseases because of the high concentration of expertise on the topic among partnership members and the lack of other large-scale consortiums focused on the topic.