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Laser Capture Molecular Core

LCM enables investigators to incorporate laser capture microdissection into research

The Laser Capture Molecular Core has been set up to enable investigators to incorporate the benefits of laser capture microdissection (LCM) in their individual research projects. Developed at the National Institutes of Health (NIH), this exciting technology helps to overcome the heterogeneity of tissue to isolate specific and pure populations of cells.

LCM technology allows researchers to mark and isolate cells from regions of tissue and cut them out, allowing for cultivation of diseased cells to be viewed while leaving out unwanted material. The process eliminates a mix-up between different cells, tissues and fats, and prevents contamination.

LCM also enables proteomic analysis using only a small, fine sample that was previously thought to be impossible. The procedure makes accurately mapping out protein and RNA in different non-responsive cells and comparing them with proteins and microRNA in normal, responsive tissues possible.

For more information, visit http://lcm.osu.edu/.

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