Advances in Electron Microscopy with Talos L120C Seminar

In order to fully understand biological processes, and how they fail in disease, it is vital to obtain structural information for the relevant biological machinery. Notably, it is becoming increasingly apparent that proteins, the key biological players in fundamental biology or disease mechanisms, often adopt multiple conformations or act in complexes with other proteins. 

Transmission electron microscopy (TEM) has been an important technology in cell and structural biology ever since it was first used in the early 1940s. The most frequently used TEM application in cell biology entails imaging-stained thin sections of plastic-embedded cells by passage of an electron beam through the sample such that the beam will be absorbed and scattered, producing contrast and an image. 

The emerging technologies focus on preserving the native ultrastructure of samples by vitrification, achievement of higher resolution, three-dimensional ultrastructure by electron tomography, and precise correlation of specific cell structures using immunofluorescence microscopy and TEM (correlative light and electron microscopy [CLEM]). The combination of these techniques is being used to cover the complete spectrum of structure, from molecular to whole cell. 

During this webinar, Senior Scientist, Natalia de Val of Thermo Fisher Scientific, will present the applications of the transmission electron microscope, Talos L120C, and results obtained from this instrument related to cancer and other important diseases. 

Our Talos L120C, provides proven optimal imaging performance on a platform designed for modular versatility, maximum stability and operational ease. It is suitable for multi-user environments supporting applications from negative stain electron microscopy (pathology samples), Single Particle Analysis (SPA), micro-electron diffraction (micro-ED) and tomography.