2017 L-Pilot Awardees

The CCTS Longitudinal (L-Pilot) program was inaugurated in 2014 to incentivize the long-term development of promising interdisciplinary projects towards major success stories (i.e. significant extramural programmatic funding and/or commercialization).

The L-pilot program has funded several interdisciplinary, multi-college teams to develop pilot studies that have the clear potential to transform healthcare or translational science through innovative clinical and translational research. Unlike traditional pilot studies which are limited in scope and time, the L-pilot program requires multidisciplinary teams to design and complete milestone driven studies to advance along the translational spectrum from Phase 1 (may be pre-clinical) to Phase 3 (health impact).

Project management support and matching funds from internal and external stakeholders such as industry represent key cornerstones of the program. Because of the longitudinal nature of the pilot funding mechanism, teams are expected to demonstrate completion of milestones and a clear path forward when they compete with other teams for funding to advance to the next phase. Here are the most recent CCTS L-pilot awards for Phase 2 and Phase 3 studies:

2017 L-Pilot Phase 2 Award:

Improving Efficacy of Anti-Leishmania Vaccine using a Novel Adjuvant Pentalinonsterol

TEAM PI: Abhay Satoskar, MBBS, MD, PhD, Professor, College of Medicine and College of Arts & Sciences

College of Medicine: Bradford McGwire MD, PhD & Narasimham Parinandi, PhD

College of Pharmacy: James Fuchs, PhD & Doug Kinghorn, PhD

College of Veterinary Medicine: Ryan Jennings, DVM, PhD

Center for Biostatistics: Xiaoli Zhang, PhD

2017 L-Pilot Phase 3 Awards:

Disposable Electroceutical Dressings to Treat Chronic Wound Biofilm Infection

TEAM PI: Sashwati Roy, PhD, Professor, College of Medicine

College of Engineering: Vish Subramaniam, PhD & Shaurya Prakash, PhD

College of Medicine: Gayle Gordillo, MD; Dan Wozniak, PhD & Hamdy El-Sayed Awad, MD

College of Nursing: Jodi McDaniel, PhD

Departments of Biomedical Informatics and Center for Biostatistics: Guy Brock, PhD

Nationwide Children’s Hospital: Chris Shilling, MS, Drug & Device Development

A Systems Biology approach to advance the understanding and treatment of Patients with Chronic Granulomatous Diseases using a Novel Ex Vivo Human Model

TEAM PI: Elliott Crouser, MD, Professor, College of Medicine

College of Medicine: Wolfgang Sadee, PhD & Peter White, PhD

College of Arts and Sciences: Avner Friedman, PhD

Consultant: Larry Schlesinger, MD, President & CEO, Texas Biomedical Research Institute

Mentees: Van Le, MD; Landon Locke, PhD & John Frater (MD/PhD)