Trial Innovation Network
The Trial Innovation Network (TIN) is new collaborative initiative amongst Clinical and Translational Science Award (CTSA) institutions in which the primary objective is to enhance multi-site trial operations by leveraging the resources and collective expertise of CTSA members to provide complementary services for all aspects of proposal development and execution. The TIN mission is to address critical roadblocks in clinical research and accelerate the translation of novel interventions into life-saving therapies.
The TIN has a two-fold functionality: it is a pathway connecting OSU and Nationwide Children’s Hospital investigators to potential collaborators from other CTSA institutions and resources to strengthen their proposals and to execute proposals better, faster, and more cost-effectively. In addition, the TIN facilitates strategic partnerships by assisting investigators from other CTSA institutions to identify collaborators at OSU and Nationwide Children’s Hospital based on targeted feasibility assessments.
The TIN is comprised of three key organizational partners:
The National Trial Innovation Centers (TICS) focus on operational excellence, operational innovation, and quality by design. The TICs responsible for coordinating and providing innovative, high-quality operational support for clinical trials. There are three TICs:
- Duke University / Vanderbilt University
- John Hopkins University / Tufts University
- University of Utah
The National Recruitment Innovation Center (RIC) focused on innovative and evidence-based approaches to participant recruitment, retention, and engagement. The RIC is responsible for providing tools and services to enhance participant recruitment and retention.
- Vanderbilt University with partners at Columbia University, University of Utah, Rockefeller University and The Ohio State University
The Local TIN Hub Liaison Team is the frontline of the TIN leading the Network at the local level by connecting the Hub to the TICs and RIC.
- The Ohio State University Center for Clinical and Translational Science (CCTS) is a TIN Hub Liaison Team
In addition, the TIN provides Trial Planning and Trial Execution Services.
Study and Budget Feasibility
Statistical Analysis Plan
Engagement and Recruitment Plans
Patient Engagement Studio
Cohort Discover Leveraging EHR
Access to unique populations - Rare Diseases
Key Opinion Leader/Clinical Expertise
Serve as a Central IRB for your multi-site proposal
Implement Standard Clinical Trial Agreements for your multi-site proposal
Provide clinical and data coordinating center services such as regulatory support, project management, data management, development of consent form and case report forms, site selection, initiation, and training, performance metrics, Data Safety Monitoring Board (DSMB), study close-out, statistical analysis, and publication
Evaluation and improvement in recruitment plans and tools
The Ohio State University Hub Liason Team
Principle Investigator: Rebecca Jackson, MD
Medical Director: William T. Abraham, MD
Administrator/Project Manager: Angela Sow, MACPR
Liason Team Staff
Tiffany Bernard, Recruitment Program Director
Jessica Evans, IRB Specialist
Aimee Nielsen-Link and Sandra Sarafin, FDP-CTSA Standard Agreements Specialists
Robert Rengel: Regulatory Affairs Specialist
Navigating the complicated clinical research landscape can be challenging especially when conducting one’s own investigator-initiated multi-site study. The goal of the TIN is to address the critical roadblocks in clinical trials and accelerate the translation of novel interventions into life-saving therapies. By focusing on operational innovation, operational excellence, and collaboration, the TIN supports investigators develop and implement multi-site clinical trials better, faster, and more cost-effectively.
- Complimentary services
- Pipeline for finding the collaborators
- Increased competitiveness of applications for NIH
- Access to expertise in multi-center operations (TICs and the RIC) enabling better implementation
If you are interested in submitting a proposal to the TIN, you must contact the OSU Hub Liaison Team first for an initial review of your proposal, brief consultation, and review by local scientific review committee. Please contact Angela Sow, TIN Hub Liaison Team Administrator at 614-247-7732 with questions.