CoRR’s integrated request management system allows for entering comments and logging work against a project or service request, communication and collaboration among service providers and the research team, and storage of project-related documents, creating a single comprehensive research record.
eagle-i is a resource discovery tool built to facilitate translational science research. Groundbreaking biomedical research requires access to cutting edge scientific resources, but those resources are often invisible beyond the laboratories or universities where they were developed.
Specialized Shared Resources
Nationwide Children's Hospital Resources
Behavioral methods play an important role in research on the health and development of children, adolescents, and adults with congenital or acquired health challenges. The Biobehavioral Outcomes Core at Nationwide Children's Hospital will assist investigators who want to incorporate behavioral assessments in their research. These assessments can include a wide variety of methods and reporting sources to assess individual, interpersonal, and social-ecological domains.
The Biostatistics Core is committed to providing outstanding service to investigators at Nationwide Children’s Hospital. The Biostatistics Core is committed to the Research Institute’s vision of supporting cutting-edge scientific research at the highest ethical standards.
This Core provides assistance to researchers in study design, data analysis, and interpretation of statistical results. For other services such as data entry, database design or data management services, the Core can provide advice on how to set up simple data management systems, and provide a referral to the Research Bioinformatics Core if complex data management services are needed.
The Cell Line Core at Nationwide Children's Hospital processes human subject samples and provides the researcher with cell lines or DNA, appropriate for downstream applications in a variety of human and molecular genetic studies. Services include extraction of DNA from saliva or whole blood, creation of EBV transformed B-cell immortalized cell lines or fibroblast cell lines from skin biopsy samples, and DNA or cell line archiving.
Clinical Research Services (CRS) at Nationwide Children's Hospital is designed to be a portal through which clinical investigators access streamlined coordination of services necessary to initiate clinical research projects, regardless of funding source. Nationwide Children's Hospital CRS supports all clinical research studies, providing staff and/or services to manage your study from beginning to end according to Good Clinical Practice and federal, state and institutional regulations and guidelines. We can also facilitate survey research, large data set analyses, and psychometrics.
The Flow Cytometry Core Lab at The Research Institute at Nationwide Children’s Hospital offers several platforms on which to do flow cytometry analysis and/or cell sorting, as well as the Nanosight NS300 for nanoparticle characterization and the Fluidigm C1 for single cell genetics studies. In addition to training and support for independent investigator use of the cores instruments, the core also provides operator assisted services and consultation for the wide array of experiments available using flow cytometry technology.
Viral Vector Core
The Viral Vector Core at Nationwide Children's Hospital supplies recombinant adeno-associated virus (rAAV) vectors of superior quality to individual research laboratories. The Core is a full-service facility assisting with the design of AAV expression cassettes for optimum levels of gene expression in target tissues that enable investigators to transition seamlessly from the bench to the bedside.
Good Manufacturing Practice
In 2009, NCH established a current Good Manufacturing Practice (cGMP) Production Facility, also known as the Clinical Manufacturing Facility (CMF). The CMF specializes in the production of recombinant Adeno-Associated viral vectors (rAAV) for use by faculty at Nationwide Children's Hospital, The Ohio State University Medical Center and external collaborators. The primary focus of the CMF is to provide researchers with the highest quality gene transfer vectors to support early phase clinical trials.
Advances in biomedical science place extreme demands on investigators for computational technology. Research Information Solutions at The Research Institute at Nationwide Children’s Hospital is working to meet those demands with a comprehensive array of computational services including biostatistics, epidemiologic analysis, database design and technical support.
Ohio State University Comprehensive Cancer Center Shared Resources
The OSUCCC Cell Analysis and Sorting Core (ACSR) Laboratory assists in the analysis and sorting of cell populations according to the expression of selective cellular markers. ACSR assists investigators with experimental design, assay development, education, and instrument training while offering cutting edge flow cytometry analysis and cell sorting on a fee-for-service basis.
The Behavioral Measurement Shared Resource (BMSR) offers assistance with integrating behavioral research into the broad research goals of the OSUCCC. BMSR also provides researchers with population based data retrieval, consultation for patient accrual procedures and locations, identification or adaptation of existing measures of behavioral constructs and guidance with behavioral data collection methodology and personnel.
The Clinical Trials Office (CTO) provides a centralized resource to facilitate the development, implementation, and management of clinical trials at The Ohio State University Comprehensive Cancer Center. The CTO staff work closely with the principal investigator of each clinical trial to ensure compliance to protocol-specific procedures.
Modeling human disease in mouse provides a powerful tool for elucidating mechanisms and interrogating experimental therapeutics. The Genetically Engineered Mouse Modeling Core (GEMMC) is available to investigators who work or intend to work with mouse models of human disease.
The GEMMC director and staff are interested in helping investigators with minimal experience who want to start using mouse models to complement and strengthen their in vivo studies or grant proposals.
The Genomics Shared Resource (GSR) provides state-of-the-art instrumentation and expertise to support research projects using genomics methods. The services provided by GSR include DNA sequencing, genotyping, real-time PCR, RNA and DNA extraction, mRNA transcriptional profiling using quantitative real0time PCR, microarrays, NanoString and/or RNA-Seq, microRNA/noncoding small RNA transcriptional profiling, single nucleotide polymorphism genotyping, other specialized forms of sequencing including methyl-sequencing and chromatin immunoprecipitation sequencing, quality control assays, and consultation.
GSR also assists researchers with their experimental designs, supports the development of novel methodologies and applications relevant to cancer research, and helps in education and training in genomics methods.
The Leukemia Tissue Bank Shared Resource (LTBSR) provides central collection, processing and a repository for tissue samples obtained from patients with all types of hematologic malignancies who are being treated or evaluated at the OSU James Cancer Hospital.
These samples are available to investigators within the OSUCCC and to outside collaborators who examine cellular and molecular properties of hematologic cancers, not just leukemia. The LTB provides investigators with training and technical support, procurement, processing, storage, retrieval and distribution of patient samples, as well as associated clinical, pathologic and molecular data for each sample. The LTB's Honest Broker status allows distribution of de-identified samples and data without the requirement for an IRB-approved research protocol.
The Medicinal Chemistry Shared Resource (MCSR) provides medicinal chemistry support to investigators at the OSUCCC – James and to other academic and commercial institutions.
MCSR integrates the expertise of multiple disciplines, including synthetic and process chemistry, instrumental analysis and molecular pharmacology, to provide medicinal chemistry support to investigators. The goal of MCSR is to provide many aspects of medicinal chemistry services, including chemistry consultations, sample purity analyses and preparations, and custom synthesis to interested investigators to identify new therapeutic targets and/or biomarkers of drug activity. From a long-term perspective, the MCSR will translate basic science findings from investigators into small-molecule agents for testing individual hypotheses, adding an important dimension to translating basic science to the clinic.
The Pharmacoanalytic Shared Resource (PhASR) supports pre-clinical and clinical drug development at Ohio State by providing high quality and cost-effective bioanalytical method development, quantitative sample analysis, and pharmacokinetic/pharmacodynamic experimental design, data analysis and modeling.
Biostatisticians vary in their area of expertise. Some focus on clinical trial design, analysis and oversight, others focus on observational study methods, laboratory experimental design and analysis, or high dimensional studies (microarray, sequence data, etc.). The inclusion of appropriate biostatistical expertise strengthens experimental designs and analyses plans, and therefore it increases the success rate for extramural funding.
Recruitment and Retention can help design those first touch points with the community and share best practices to help researchers achieve their recruitment/retention goals. Requesting a consultation with Recruitment and Retention Services early in the design of a research study can help to reduce the burden of study participant recruitment, which can often be more challenging than expected.
The Center for HOPES was established in 1994 to respond to the needs of healthcare policy decision-makers at local, state, and national levels. The Center for HOPES, which is located at OSU's College of Public Health, conducts applied health services research studies to help public and private organizations evaluate clinical effectiveness, quality of care, costs of medical services, process flow in health care institutions, and other investigations in the areas of health outcomes, policy, and evaluation. Our programs have a direct and strong impact on health care in both the private and public sectors at the local, state, and national levels.
In collaboration with the CCTS, the Informatics Research and Development Research Informatics Services provides investigators, trainees, and research staff at OSU and Nationwide Children’s Hospital with access to state-of-the-art biomedical informatics expertise, technologies and data management platforms.