Comparative Translational Research: Developing a Novel ARDS therapy in Dogs with Aspiration Pneumonia

Ian C. Davis, PhD, and Anda Young, DVM, both of The Ohio State University College of Veterinary Medicine, used client-owned dogs admitted to the small animal ICU at the Ohio State Veterinary Medical Center as a "real-world" model to test the repurposing of an old drug, citicoline, as a treatment for hypoxemic acute respiratory failure. Citicoline was developed for neurologic conditions, but Dr. Davis had found that it worked to treat respiratory failure in mice. The dogs in the study suffered from hypoxemic acute respiratory failure associated with aspiration pneumonia. Because the Vet school ICU closely mimics the human ICU in terms of clinical practice, Drs. Davis and Young were able to assess treatment efficacy in a natural disease state in outbred animals of different ages and both sexes. Come to learn about how they came to use this model and their results. 

This is the second in a series of seminars presented by the Ohio State Center for Clinical and Translational Science Comparative and Translational Medicine program to highlight how the use of spontaneous animal models of disease can create an integrated platform for collaborative research, therapeutic interrogation, cross-disciplinary training and outreach across Ohio State, Nationwide Children's Hospital and partners

Presenters:

Ian C. Davis, BVSc (hons), PhD, ATSF
Professor
Department of Veterinary Biosciences 
College of Veterinary Medicine

Anda Young, DVM, MS, DACVECC
Assistant Professor-Clinical
Department of Veterinary Clinical Sciences
College of Veterinary Medicine

Questions: stuart.hobbs@osumc.edu